Is it possible to give in a brief statement the central theme of all the Upanishads?
The Isha Upanishad embodies in its very opening verse the central theme of all the Upanishads, namely, the spiritual unity and solidarity of all existence.
ॐ ईशा वास्यमिदं सर्वं यत्किञ्च जगत्यां जगत् ।
(Om Isavasyamidam sarvam yatkinca jagatyam jagat;) 1
‘Whatever there is changeful in this ephemeral world, all that must be enveloped by the Lord.'
The whole universe, it tells us, is filled with the spirit of God.
Reference: The Message of the Upanishads by Swami Ranganathananda (p.1,75)